South Africa has one of the highest incidence rates of Mycobacterium tuberculosis (TB) in the world, with annual notification rates in some areas in the Western Cape exceeding 1000/100000. Moreover, SA has one of the world’s largest human immunodeficiency virus (HIV) epidemics, an estimated 5.54 million people being infected.  Thanks to some of world’s foremost pioneers in TB research and treatment, there is hope.  Warren Mac Carthy directed with Georgia Court on camera for websedge.com and Aeras.org.